Slay the Spire 2 official cover art

Your first run: what to do at every stop

Quick answer

Start as Ironclad, look ahead to the boss, then choose cards that solve the fights you can already see. You do not need a perfect deck or a winning run to unlock the next character.

Analyze your runs →

How this guide was checked

Coverage: Early Access · Main 0.107.1 · optional Beta 0.111.0 · next beta planned November 12 · official sources checked November 4, 2026 UTC. Research checked 27 Sep 2026. Updated 25 Oct 2026

This guide uses the linked sources and any attributed demonstrations. Platform differences and limitations are noted with the advice they affect.

See the 4 sources
4 sources
Creator clipChecked on screen · 25 Oct 20263 steps1 moment · 0:21
  1. 0:35–0:56Reading the Act 1 map and tracing a routeChoose a route you can survive · zpsKai

See it first · Choose a route you can survive ↓

Checked on screen · Oct 25, 2026

0:35–0:56 · 21 sReading the Act 1 map and tracing a route
zpsKaiFull video ↗
Credits

“Sovereign Blade, Summon Forth, Repeat | A10 Regent STS2” by zpsKai · Sep 17, 2026 · Uploaded Sept 17, 2026, after Main 0.107.1; build not readable on screen

Independent creator · no partnership implied

Creator? Ask us to remove this

Before you start

  • Default Steam Main branch; this edition uses the 0.107.1 baseline.
  • Leave optional mods off while learning the ordinary rules.
1

Unlock the roster

Play a run as Ironclad to unlock Silent, then a run as Silent for Regent, Regent for Necrobinder, and Necrobinder for Defect. A loss still counts; the published unlock guide also reports that abandoning counts.

Try one full run before rushing through the roster. Ironclad teaches the basic turn economy; Silent adds discard, Regent adds Stars, Necrobinder adds Osty, and Defect adds Orbs.

Sources for this section
2

Choose a route you can survive

Checked on screen · Oct 25, 2026

0:35–0:56 · 21 sReading the Act 1 map and tracing a route

When an act's map opens, use the Legend to read each node, follow the branches, and trace your route up to the boss icon at the top, checking where Rest sites sit before you commit to an Elite.

zpsKaiFull video ↗
Credits

“Sovereign Blade, Summon Forth, Repeat | A10 Regent STS2” by zpsKai · Sep 17, 2026 · Uploaded Sept 17, 2026, after Main 0.107.1; build not readable on screen

Independent creator · no partnership implied

Creator? Ask us to remove this

0:35–0:56Reading the Act 1 map and tracing a route
  1. Inspect the boss icon and the branches leading to it.
  2. Choose early combats for rewards, with a reachable rest site or a safer branch before a risky elite.
  3. Reconsider the path after an expensive fight. A route chosen at full health may be wrong after two bad hands.
StopUse it for
CombatCards and resources; evaluate the reward before accepting.
EliteA harder fight with a relic reward.
Rest siteHealing or an upgrade.
ShopA specific purchase or removal you can afford.
EventRead the actual choice and its cost.
Sources for this section
3

Make a complete turn before clicking

Add up incoming attacks, then check whether killing one enemy removes more damage than blocking. Apply modifiers before the attacks they improve. Keep enough Energy for the defense you intend to play.

Kingy example: if one enemy intends 8 damage and another 12, killing the first removes 8 from the turn. Your remaining Block decision concerns the survivor. Recalculate when an effect changes an intent; do not rely on the starting total.

Mega Crit’s Early Access trailer introduces the sequel’s characters and cooperative play.

Mega Crit · 0:00 · Full video 2:22

Source & footage context

February 2026 promotional footage. The trailer predates later Early Access balance updates.

Source record ↗ · Checked 2026-09-13

Preview artwork: Mega Crit · official press imagery. This is an illustration beside the video, not a frame from the selected timestamp.

The original creator hosts the recording. If playback is restricted, use the YouTube link.

Sources for this section

You’re ready when…

Your checklist

0 of 3 complete · Loading saved progress…

Did this answer your question?

Sources · 4Walkthrough · checked 12 Sep 2026 · Research checked 27 Sep 2026
Beginner guide ↗Unlock sequence and basic map rules; older 0.104-labelled guide.Walkthrough ·
Combat basics ↗Main 0.107.1 combat decision rules.Walkthrough ·
Pathing and deckbuilding ↗Route and draft principles.Walkthrough ·
Character comparison ↗Character systems; no strength ranking.Walkthrough ·

Stuck? Tell us where

Say where you’re stuck in Slay the Spire 2. You get one hint at a time from a published kingy.wiki guide, and the answer and its clip stay covered until you ask.

If nothing matches, we keep your words (without emails, links or long numbers) to decide which answers to write next. Privacy